Indeed, the synthesis of inflammatory mediators is induced or strongly increased when periodontitis-associated bacteria release the CD147 bound to the OSCC cell membrane into a diffusible form that homodimerizes with the CD147 anchored on the surface of neighbor cells, including fibroblasts, OSCC cells, and normal epithelial, endothelial, or inflammatory cells (Table 1) [27,103]. This evidence concerns the gene BSG and periodontitis.