On the other hand, 24 h and 48 h of stimulus with 50% or 100% OA SF significantly increased the gene levels of MMP-1, MMP-13, and ADAMTS-5 (p < 0.05, p < 0.01), whereas it decreased the levels of Col2a1 (p < 0.01, p < 0.001) in comparison to the baseline; 50% or 100% RA SF induced similar effects on the expression of matrix degrading enzymes and Col2a1 (p < 0.05, p < 0.01, p < 0.001) (Figure 3A–H). Here, COL2A1 is linked to rheumatoid arthritis.