Our data demonstrated, for the first time, the role of SF in modulating the expression levels of miR-34a, miR-146a, miR-155, and miR-181a, mainly involved in inflammation and cartilage metabolism occurring in OA and RA; moreover, the observed transcriptional modifications of miRNA seem to be due to the modulation of the NF-κB signaling pathway. Here, NFKB1 is linked to rheumatoid arthritis.