In particular, in RA and OA, the SF is characterized by an increased content of inflammatory mediators (prostaglandin E2, leukotriene B4), cytokines (interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α), nitric oxide (NO), and reactive oxygen species (ROS), released from chondrocytes, synoviocytes, and WBCs, which contributes to articular cartilage degradation [3,5,8,15,16]. The gene discussed is TNF; the disease is rheumatoid arthritis.