H19 and breast cancer: Si et al. (2016) [59] demonstrated that upregulation of H19 in MCF-7 cell line inhibited transcription of BCL-2 interacting killer protein (BIK)—a proapoptotic BH3-only member of the BCL-2 family which is prognostic for relapse and decreased overall survival of breast cancer [60]—by recruiting EZH2 subunit to the promoter of this gene, modulating H3 methylation at lysine 27.