Furthermore, H19 blocks miR-340-3p function—a known tumor suppressor miRNA involved in repression of EMT—acting as competitive sponge and avoiding degradation of tyrosine 3-monooxygenase/tryptophan 5-monoixygenase activation protein (YWHAZ), which in turn enhances activation of Wnt/β-catenin signaling pathway. Here, H19 is linked to neoplasm.