PARP1 and childhood malignant neoplasm: Even though PARP1 is upregulated in several types of carcinomas and PARP1 inhibitors have been described as pivotal drugs against tumorigenesis, PARP1 has been shown to increase the antitumor activity of other drugs such as temozolomide and topotecan in preclinical studies, including models of pediatric cancers [70,71,72].