Epidermal growth factor receptor (EGFR) signaling is a receptor tyrosine kinase (RTK) mediated signaling commonly upregulated in many different tumors such as non-small-cell lung cancer, metastatic colorectal cancer, glioblastoma, pancreatic cancer, and breast cancer [80,81,82]. The gene discussed is EGFR; the disease is metastatic colorectal cancer.