Notably, while we have discussed the clearance of toxic substances by P2X7R- and P2Y6R-mediated phagocytosis in the context of RIBI treatment, recent studies reported that blocking P2Y6R inhibited microglia phagocytosis and prevented LPS, amyloid-β protein (Aβ), and tauopathy (tau)-induced neuron loss and death, indicating the possibility for detrimental effects of P2Y6R-mediated phagocytosis [165,252]. Here, MAPT is linked to tauopathy.