CYP3A4 and hepatocellular carcinoma: Among them, typical liver cancer stem cell markers such as AFP and keratin 19 (KRT19) were upregulated in FOXM1-high HCC, whereas typical mature hepatocyte markers such as solute carrier organic anion transporter family member 1B1 (SLCO1B1) and cytochrome P450 3A4 (CYP3A4) were downregulated (Figure 2B).