Among them, typical liver cancer stem cell markers such as AFP and keratin 19 (KRT19) were upregulated in FOXM1-high HCC, whereas typical mature hepatocyte markers such as solute carrier organic anion transporter family member 1B1 (SLCO1B1) and cytochrome P450 3A4 (CYP3A4) were downregulated (Figure 2B). This evidence concerns the gene CYP3A4 and liver cancer.