GSDMD and Yersinia infectious disease: For instance, activated caspase-8 cleaves gasdermin D (GSDMD) during Yersinia infection, causing the formation of inflammasome [101,102], and activated caspase-3 can cleave GSDME, inducing pyroptosis and lung necrosis [103], and activated caspase-6 promotes inflammasome formation though activating the ZBP1-RIPK3 complex and induces a strong inflammatory response upon IAV infection [104].