Similarly, it has been shown that exposure to the estrogen disruptor, 2,2′,4,4′-tetrabromo diphenyl ether-47 (BDE-47), attenuates the sensitivity of endometrial carcinoma cells to Cp, thus eliciting chemoresistance, at least in part via a GPER1 signaling pathway [70]. The gene discussed is GPER1; the disease is endometrial carcinoma.