Although various recent studies have suggested that GPER1 signaling elicits protective actions against cardiac [25,30,31,32,33], cerebral [34,35], renal [18], hepatic [36], and intestinal [37] injury induced by ischemia reperfusion, whether GPER1 confers protection against Cp-induced kidney damage is not known. The gene discussed is CP; the disease is Nephropathy.