Furthermore, there are also data postulating that the disruption of CX3CL1/CX3CR1 communication by the deletion of the cx3cr1 gene causes neurotoxicity in mouse models of systemic inflammation PD and ALS [52] but protects against neuronal loss in a mouse model of focal cerebral ischemia [51]. This evidence concerns the gene CX3CL1 and Cerebral ischemia.