In the APP/PS1 mouse, metformin effectively reduces brain Aβ plaque accumulation levels by stimulating transforming growth factor beta-activated kinase 1 (TAK1)—inhibitory kappa B kinase α/β (IKKα/β)—heat shock cognate protein 70 (Hsc70) signaling pathway to induce chaperone-mediated autophagy (CMA) activation, which is a lysosomal-dependent selective degradation pathway involved in the pathogenesis of cancer and neurodegenerative diseases [118]. Here, MAP3K7 is linked to neurodegenerative disease.