The role of diverse FAs metabolism-related enzymes and regulators in metabolic inflexibility-induced AF are still under debate, especially these involved in triglyceride turnover (diacylglycerol transferase/DAGT, acetyl-CoA carboxylase/ACC, and adipose triglyceride lipase/ATGL), FAO (malonyl-CoA decarboxylase/MCD and carnitine acetyltransferase/CrAT) and FAs delivery (FABP). The gene discussed is MLYCD; the disease is atrial fibrillation.