F8 and blood coagulation disease: Different coagulopathies have been described, including von Willebrand’s disease (deficiency of vWF), hemophilia A (deficiency of FVIII), hemophilia B (deficiency of FIX), FXI deficiency, and several alterations in other clotting factors, such as deficiencies of fibrinogen, prothrombin, FV, FVII, and FX, among others [233].