Even though not much is known about the exact role of FVIII in neoangiogenesis during embryonic development, work on adult mouse models with hemophilia A has revealed the formation of large and irregular vessels, with high concentrations of vascular remodeling markers, such as αSMA, endoglin, and VEGF, in addition to the formation of an abnormal vasculature following induction of hemarthrosis [184]. Here, F8 is linked to hemarthrosis.