The simultaneous presence of sarcopenia and obesity is associated with both oxidative stress and a proinflammatory state (as indicated by high levels of TNF-α, IL-1b, IL-6, IL-8, IL-12, and hs-CRP), is also associated with an increased risk of CVD [82,83]; this excess of cytokines decreases muscle anabolism by facilitating muscle atrophy, modifying the function and proliferation of immune cells [84], which may explain the elevated levels of IL-6 and Th17 cells in SO patients with COVID-19. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.