Clopidogrel withdrawal in patients with diabetes on long-term (12 months) dual antiplatelet therapy (aspirin plus clopidogrel) showed a significant increase in effects on platelet aggregation (ADP aggregation) and inflammatory biomarkers (C-reactive protein, P-selectin expression in resting platelets, and P-selectin expression in ADP-stimulated platelets) [197]. This evidence concerns the gene CRP and diabetes mellitus.