Chronic or poorly controlled hyperglycemia increases the production of several profibrotic factors such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), and connective tissue growth factor/CCN family member 2 (CTGF/CCN2) and contributes to fibrotic connective tissue accumulation characterized by elevated fibronectin and collagen levels [51]. This evidence concerns the gene TGFB1 and Hyperglycemia.