Similarly, Ge’s group reported a series of amphiphilic block copolymers, which could self-assemble into micelles or vesicles to load drugs, in which hydrophilic PEG linked with hydrophobic segments via MMP-2-sensitive peptide GPLGVRGDG; these systems could also achieve the “tumor-triggered targeting” and intracellular DOX release [114,115,116]. This evidence concerns the gene MMP2 and neoplasm.