LRP1 and glioblastoma: By coating the lipid nanoparticles with both angiopep-terminated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-PEG2000 (DSPE-PEG2000) and dimyristoyl-PEGylated cleavable lipopeptide (DM-PCL), the carriers could anchor the overexpressed low-density lipoprotein receptor-related protein-1 (LRP-1) through the targeting ligand angiopep firstly and then take off the PEG protection layer, due to the MMP-degradation of the GWIPVSLRSGEE peptide of DM-PCL for uptake by brain endothelial and glioblastoma cells, which achieved the crossing of the BBB.