ANGPT2 and neoplasm: Other proangiogenic factors that have been shown to be important in tumour neoangiogenesis are members of the fibroblast growth factor (FGF) family; they exert their function by stimulating FGFR receptors on endothelial cells and inducing them to release other angiogenic factors—angiopoietin 2, VEGF-β, hedgehog.