In addition, TGF-β can also generate myofibroblasts in the peritumoural stroma from stromal precursor cells [186], called tumour-associated myofibroblasts, which facilitate tumour development by their ability to produce matrix metalloproteinases, cytokines (IL8) or chemokines (CXCL12). This evidence concerns the gene TGFB1 and neoplasm.