Sedghizadeh et al. [71] reported in their meta-analysis of 18 studies that p16 overexpression improved the survival of patients with oropharyngeal carcinoma 2.77-fold, which is to be expected as p16 is essentially overexpressed in HPV+ cases, which are known to behave in a more benign manner. Here, CDKN2A is linked to oropharyngeal carcinoma.