Finally, there is very scarce information on mechanisms related to genomic instability, on the hallmark related to reprogramming of energetic metabolism, where five meta-analyses have a reported poor prognosis of oral cancer associated with overexpression of glucose transporters, and in relation to immune evasion, where one meta-analysis has documented poor prognosis associated with PD-L1 overexpression. Here, CD274 is linked to lip and oral cavity carcinoma.