There was a 2.8-fold increased percentage for HLA-A*25 (normal 8/172, tumor 11/84, p = 0.02) and a 2.1-fold increase in HLA-C*06 (normal 21/172, tumor 21/84, p = 0.01) in HNSCC patients. This evidence concerns the gene HLA-C and head and neck squamous cell carcinoma.