CXCL12 plays a key role in cancer progression by binding directly to CXCR4 expressed on cancer cells, promoting proliferation and invasiveness [8,9] and indirectly by recruiting tumor immunosuppressive cells [10,11] or by sequestering T cells in the tumor stroma as shown in several PDAC studies [6,12]. This evidence concerns the gene CXCR4 and neoplasm.