Our data also suggest that the ligands for the chemokine receptors CXCR3 (CXCL9, CXCL10, CXCL11) and CCR5 (CCL8) might affect the spatial distribution of CD8+ T cells in human pancreatic tumor tissues and enhance the relative T cell trafficking into tumor rich areas. This evidence concerns the gene CCL8 and pancreatic neoplasm.