After AOM/DSS treatment, Rig-I−/− mice given an antibiotic cocktail were found to be more susceptible to colitis, suggesting that intestinal microbiome imbalance is not the main cause of the high susceptibility and that Rig-I mediated signaling may play a major role in determining the host susceptibility to CRC [54]. The gene discussed is RIGI; the disease is infectious otitis media.