In spite of the heterogeneity of the studies and the wide variability in the sample analyzed, with this systematic review we can affirm that [68Ga]Ga-Pentixafor PET/CT or PET/MRI has a high detection rate and diagnostic performances for the evaluation of several lymphomas, especially MZL, CNSL, and LPL. The gene discussed is LPL; the disease is marginal zone lymphoma.