SMARCA1 and neoplasm: Synovial sarcoma is molecularly characterized by translocation t(X;18)(p11;q11), which forms a fusion gene between SS18 (SYT) on chromosome 18 and SSX1, SSX2, or SSX4 on chromosome X. SS18 is a subunit of SWI/SNF (BAF) complexes, and the SS18/SSX fusion protein alters SWI/SNF composition, in which a tumor suppressor, SMARCB1, is lacking [83].