In addition, RNA splicing is frequently dysregulated in a variety of cancers, and hotspot mutations affecting key splicing factors, SF3B1, SRSF2, and U2AF1 are commonly enriched across cancers [19,20], strongly suggesting that aberrant RNA splicing is a new class of hallmark that contributes to the initiation and/or maintenance of cancers. This evidence concerns the gene SF3B1 and cancer.