Another member of the TNF family involved in this stromal training is TNFα, which induces the expression of adhesion molecules, such as LFA-1, ICAM-1, VCAM-1, and VLA-4 on MM cells, as well as ICAM-1 on BM-MSCs, resulting in increased binding of MM cells to BM-MSCs and further enhancing IL6 secretion [54]. Here, TNF is linked to Miyoshi myopathy.