Moreover, the integrin lymphocyte function-associated antigen 1 (LFA-1) on MM cells and its transmembrane binding partner Mucin 1 (MUC1) bind to ICAM-1 in adjacent BM-MSCs, resulting in the activation of different pathways associated with poor prognosis and disease progression in patients [40]. The gene discussed is ICAM1; the disease is Miyoshi myopathy.