In turn, endothelial cells in MM will produce IGF1 and IL6 to promote MM cell growth, causing an autocrine loop in endothelial cells, which will enhance their production of VEGF, platelet-derived growth factor (PDGF), Ang-1, HGF, and IL1 to promote angiogenesis constantly [90]. This evidence concerns the gene IGF1 and Miyoshi myopathy.