CXCR4 and Miyoshi myopathy: Strategies used in the clinic to disrupt these MM–ECM interactions and reduce cell adhesion-mediated drug resistance include the CXCR4 inhibitor AMD3100 or the proteasome inhibitor bortezomib, which downregulates VLA-4 on MM cells [34], leading to the de-adhesion of MM cells from the BM and turning them more sensitive to therapeutic agents [35].