Regarding studies comparing p16 performance for diagnosing an HPV-driven oral cavity, laryngeal, and oropharyngeal HNC, the group of Dr. Maura L. Gillison in the USA assessed the accuracy of two different criteria for p16 positivity in HPV-related OCC, OPC, and LC [18,19,20]. This evidence concerns the gene CDKN2A and laryngotracheoesophageal cleft.