CDKN2A and laryngotracheoesophageal cleft: When considering as HPV-positive those cases double-positive for HPV-DNA/HPV-E6*I mRNA or HPV-DNA/p16INK4a, the percentage of HPV16-positive cases increased for OCC (96.0%, 85%) and OPC (89.0%, 87.0%) and decreased for LC (41.0%).