When considering only cases where HPV was the truly triggering carcinogenic agent (i.e., cases HPV-DNA/HPV-E6*I mRNA double-positive) or HPV-DNA/p16INK4a double-positive cases, the percentage of HPV16-positive cases increased for OCC and OPC, but decreased for LC. The gene discussed is CDKN2A; the disease is laryngotracheoesophageal cleft.