In addition, an open label, phase Ib clinical trial is examining naporafenib (LXH254, a RAF inhibitor) in combination with either LTT462 (an ERK1/2 inhibitor), trametinib, or ribociclib (a CDK4/6 inhibitor) in NRAS or BRAFV600 mutant melanoma and non-small cell lung cancer. Here, CDK4 is linked to melanoma.