A phase Ib, multicenter, open-label trial is currently evaluating the safety profile of belvarafenib (a pan-RAF inhibitor) as a single agent or in combination with either cobimetinib or cobimetinib plus atezolizumab (PD-L1 inhibitor) in patients with NRAS-mutant melanoma previously treated with anti-PD-1/PD-L1. This evidence concerns the gene PDCD1 and melanoma.