VEGFA and neoplasm: PsP may constitute an over-response to effective therapy and is likely associated with endothelial damage, BBB disruption, oligodendroglial injury, cellular hypoxia and the upregulation of the vascular endothelial growth factor (VEGF), leading to increased vessel permeability and edema or increased tumor enhancement; another explanation is the increased capillary permeability induced by radiotherapy [4].