Taking into consideration the biochemical recurrence status of the samples (where available), we were able to identify seven proteins (NMP1, UQCRH, HSPA9, MRPL3, VCAN, SERBP1, HSPE1) as common denominators of PCa aggressiveness and persistence, which could potentially be used for the development of risk assessment tools. Here, HSPA9 is linked to posterior cortical atrophy.