Enrichment analysis of the significant changes between the two groups suggested differences in the TCA cycle [55,56], mitochondrial metabolism [57,58], angiogenesis [50,51], Rho GTPases [53], extracellular matrix organization [59], and ALK signaling [60], which have been associated with PCa aggressiveness and/or recurrence before. The gene discussed is ALK; the disease is posterior cortical atrophy.