KDR and posterior cortical atrophy: Apart from the metabolic reprogramming, processes related to angiogenesis (neutrophil and platelet degranulation, VEGFA-VEGFR2 signaling pathway) [50,51], apoptosis [52], Rho GTPases [53], and reactive oxygen species signaling [54] are shown to be altered among the grade groups and have been previously linked to PCa and disease progression, which further supports the validity of our findings.