Notably, two glycoproteins, N-acylethanolamine acid amidase (NAAA) and protein tyrosine kinase 7 (PTK7) [38] and proneuropeptide-Y (pro-NPY) [39], were shown to be predictive of PCa aggressiveness by tissue proteomic studies and were validated independently by immunohistochemistry. Here, PTK7 is linked to posterior cortical atrophy.