Conditioned medium derived from adipose mesenchymal stem cells induces increased expression of C-terminal Src kinase (Csk)-binding protein (Cbp), accompanied by enhanced cell proliferation and chemotherapy resistance in MCF-7/ADR breast cancer cells. Depletion of Cbp in breast cancer cells by RNA interference leads to remarkable inhibition of cell proliferation and invasion as well as synergy with adriamycin hydrochloride to suppress tumour growth. Here, CSK is linked to breast carcinoma.