MSC co-culture improves stemness and drug-resistance of gastric cancer (GC) cells. LncRNA histocompatibility leukocyte antigen complex P5 (HCP5) is induced in GC cells by MSC co-culture, contributing to stemness and drug resistance. MSC-induced lncRNA HCP5 drives FAO throughmiR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of GC. The gene discussed is PPARGC1A; the disease is gastric cancer.