E2F1 and breast cancer: To explore this idea in more detail, publicly available datasets of chromatin immunoprecipitation followed by sequencing (ChIP-seq) were queried to determine whether known oncogenic transcription factors could bind the promoters of the genes from the list of 24 mitotically relevant genes identified in Figure 1A. MYB2L, FOXM1, and E2F1 were selected for further analyses because previous studies found that these three transcription factors were overexpressed and highly correlated with aneuploidy status in all four BC subtypes (HER2, lumA, lumB and basal subtypes) [12].