GAL opened adenosine triphosphate (ATP)-sensitive K+ channels and hyperpolarized cell membranes in the rat RINm5F insulinoma cell line [214], and the peptide blocked the activity of AC and the secretion of insulin via the interaction with Gαi1, Gαi2 and Gαi3 proteins [53,215]. This evidence concerns the gene GAL and pancreatic insulinoma.