TACR1 and neoplasm: Some peptidergic systems (e.g., substance P/neurokinin-1 receptor system, neurotensinergic system) exclusively promote the proliferation of tumor cells; however, GAL, via different GALRs, exerts a tumor cell proliferative action, but also the peptide suppresses the development of tumors [8,11,12,13,102,122,157].