Under the conditions of AR inhibition or AR deficiency, the PCA tumors can downregulate FKBP5, leading to the downregulation of PHLPP, which negatively regulated PI3K-AKT-mTOR signaling; thus, engaging this signaling pathway and contributing to enhanced tumor cell proliferation and survival, facilitating the acquisition of androgen-independent growth characteristics [142,153,154,155]. The gene discussed is AR; the disease is neoplasm.