In the high-risk group, calcium signaling pathway, mitogen-activated protein kinase signaling pathway, focal adhesion, Rap1 signaling pathway, systemic lupus erythematosus, Ras signaling pathway, phosphatidylinositol 3-kinase/AKT signaling pathway, regulation of actin cytoskeleton, transcriptional dysregulation in cancer, and neuroactive ligand-receptor interactions were highly enriched in KEGG pathway analysis. Here, AKT1 is linked to systemic lupus erythematosus.