Other examples of frequently associated malignancies and syndromes are juvenile myelomonocytic leukemia (JMML) in patients with NF1 and Noonan syndrome [44,45]; hypodiploid acute lymphoblastic leukemia (ALL) and choroid plexus carcinoma in children with LFS [46,47]; medullary thyroid carcinoma (MTC) and multiple endocrine neoplasia type 2 (MEN2) [48]; pleuropulmonary blastoma and DICER1 PV [49,50]; pheochromocytoma and VHL, NF1, MEN2 [29,51]; pheochromocytoma and paraganglioma in SHDx-mutation carriers [52]. The gene discussed is NF1; the disease is acute lymphoblastic leukemia.