Following EV uptake, HSCs facilitated CRC cell migration, invasion, and metastasis formation by increasing expression of α-SMA and fibronectin in the liver ECM while reducing vitronectin and tenascin C. Moreover, they also secreted CCL20 into circulation, which upregulated further miR-181a-5p production by primary tumor cells in a positive feedback loop [25]. This evidence concerns the gene FN1 and colorectal carcinoma.