Using a KC (LSL-Kras+/G12D; Pdx1-Cre) pancreatic cancer model, Bernhard Renz et al. [82] revealed that chronic restraint stress (CRS) facilitated β2-AR-dependent PDAC growth, NGF secretion and intratumoral neural density. The gene discussed is ADRB2; the disease is familial pancreatic carcinoma.