CLDN4 and ovarian carcinoma: Furthermore, proteins from sEVs, including claudin-4, transforming growth factor-β1 (TGF-β1), and melanoma-associated antigen 3 and 6 (MAGE3/6), were considered as candidate biomarkers because of their enrichment in the serum of ovarian cancer patients compared to that in the patients with benign tumors or healthy controls [15,16].