Trying to harmonize IHC/FISH criteria, some authors suggest that CRC can be diagnosed as ERBB2+ with NGS if a copy number variant (CNV) of ≥ 5.0 is found in NGS, while CNV of 4.0 and 4.9 should be confirmed by IHC/FISH. Here, ERBB2 is linked to colorectal carcinoma.