Regarding the 3p21.31 locus, this region contains the SETD2 gene, which encodes a histone methyltransferase involved not only in the regulation of gene transcription but also in maintenance of genomic stability, and whose inactivation was also found to be associated with genomic complexity, del/mutTP53, cth and aggressive disease [24,36]. Here, PRDM9 is linked to aggressive behavior.