In the PI3K pathway, mutations occur in PIK3 elements encoding the regulatory subunits PIK3R1, PIK3R5, or the catalytic subunit PIK3CA in 7% of AITL and Tfh-like PTCL [2] and 1% of CTCL [28]. Here, PIK3CG is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.