The Ras homolog family member A (RHOA) gene is one of the most frequently mutated genes with its mutations detected in 50–71% of AITL [2,25,26], 8–18% of PTCL-NOS [25], 5% of cutaneous T-cell lymphomas (CTCL) [28], and 8% of adult T cell leukemia/lymphoma (ATLL) [23]. This evidence concerns the gene RHOA and adult T-cell leukemia/lymphoma.