In the PI3K pathway, mutations occur in PIK3 elements encoding the regulatory subunits PIK3R1, PIK3R5, or the catalytic subunit PIK3CA in 7% of AITL and Tfh-like PTCL [2] and 1% of CTCL [28]. The gene discussed is PIK3CG; the disease is angioimmunoblastic T-cell lymphoma.