Other hereditary CRC syndromes worth noting include Peutz–Jeghers syndrome (PJS) caused by a mutation in Serine/threonine kinase 11 (STK11), usually presenting as multiple benign hamartomatous polyps [42,43], and MUTYH-associated polyposis (MAP) inherited in an autosomal recessive pattern characterized by biallelic germline mutations in MutY DNA glycosylase (MUTYH), a gene having a role in base excision repair (BER) [26,44]. This evidence concerns the gene STK11 and Peutz-Jeghers syndrome.