Inhibin subunit beta B (INHBB), SPARC related modular calcium binding 2 (SMOC2), brain derived neurotrophic factor (BDNF), and transforming growth factor beta regulator 4 (TBRG4) are highly deregulated by methylation and are involved in CRC metastasis development. The gene discussed is TBRG4; the disease is colorectal carcinoma.