They are thought to contribute to CRC development and progression by affecting wingless-related integration site/beta-catenin (WNT/β-catenin), phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), EGFR, NOTCH, mammalian target of rapamycin (mTOR) and TP53 signaling [132]. The gene discussed is TP53; the disease is colorectal carcinoma.