RNF135 and glioblastoma: For instance, in prostate cancer cells, miR-485-3p was shown to inhibit proliferation, migration and invasion by targeting the TGFBR2 (Transforming Growth Factor Beta Receptor 2) gene, a key regulator of the TGF-β signaling pathway [69], while in glioblastoma cells, the inhibitory effects of miR-485-3p on proliferation and migration were linked to downregulation of the RNF135 (Ring Finger Protein 135) gene and impairment of the ERK1/2 signaling pathway [70].