In renal carcinoma cell lines, miR-1246 was shown to target CXCR4 (C-X-C Motif chemokine receptor 4) leading to impairment of proliferation and migration [55], while in prostate cancer cells, CDH2 (Cadherin 2) and VIM (Vimentin) were identified as direct miR-1246 target genes involved in its suppression of epithelial to mesenchimal transition (EMT) [54]. The gene discussed is CDH2; the disease is Familial prostate cancer.