MELK and osteosarcoma: Other target genes whose negative modulation by miR-485-3p has been shown to impair tumor growth and metastasis include, among others, ZEB1 (Zinc Finger E-box Binding Homeobox 1) and BIRC5 (Baculoviral IAP Repeat Containing 5) in breast cancer cells [72,79], MELK (Maternal Embryonic Leucine Zipper Kinase) and JAK2 (Janus Kinase 2) in CRC cells [74,80], MET and AKT3, in osteosarcoma cells [75].