SPRED2 and lung cancer: Several other target genes of miR-1246 involved in its oncogenic activity have been experimentally identified, including, among others, GSK3B (Glycogen Synthase Kinase 3 Beta) in lung cancer cells, SPRED2 (Sprouty Related EVH1 Domain Containing 2) in CRC cells, CADM1 (Cell Adhesion Molecule 1) in hepatocellular carcinoma cells [50], NFE2L3 (NFE2-like bZIP transcription factor 3) in breast cancer cells [51].