TGFB1 and neoplasm: Interestingly, other signaling molecules that interact with CRIPTO, such as the soluble factors Transforming Growth Factor β (TGFβ) or Lefty, induce a pleiotropic reaction that leads to a diverse and varied set of responses that range from cytostatic and apoptotic tumor-suppressive ones, to proliferative, invasive, angiogenic, and oncogenic ones [77,78,79,80].