Importantly, GBM-derived exosomes also contain different components, including (a) melanoma-associated antigen 1 (MAGE-1 protein), a specific antigen for the glioma tumor, (b) major histocompatibility complex class I (MHC-I), an essential factor for antigenic peptide capturing, (c) 70 kilodalton heat shock proteins (Hsp70s), a critical chaperone for binding to the DCs, and (d) intercellular adhesion molecule-1 (ICAM-1), a transmembrane glycoprotein useful for cell targeting and immune response activation. The gene discussed is MAGEA1; the disease is glioblastoma.