The BMPR1A nonsynonymous SNV (rs55932635) was identified in one of 56 BRCA-negative breast cancer patients in Puerto Rico [52], while the JAK2 nonsynonymous SNV (rs200018153) was found in one of 1487 acute myeloid leukaemia (AML) patients in the United States [53]. The gene discussed is BMPR1A; the disease is breast carcinoma.