In addition, germline mutations associated with increased cancer risk have been reported in over 100 genes [17], and targeted sequencing has found variants in suspected familial or sporadic NPC susceptibility genes CDKN2A/2B, BRD2, TNRFRSF19, and CLPTM1L/TERT [18]. This evidence concerns the gene BRD2 and nasopharyngeal carcinoma.