To assess the Ag specificity of memory CD4 Tconv according to PD-1 and CD39 expression, we selected patients with HPV 16- or 18-induced HNSCC or CC and sorted ex vivo DN, PD-1s, and CD39+ memory Tconv cells from their PBMCs. The gene discussed is ENTPD1; the disease is head and neck squamous cell carcinoma.