BAP1 and neoplasm: Consistent with these findings, multicolor immunohistochemistry in human class1/BAP1-wildtype and class2/BAP1-mutant UM samples revealed a significant association between BAP1 loss and PROS1 upregulation in UM cells and MERTK phosphorylation in tumor-associated macrophages (Table 1, Figure 3A and Supplementary Figures S3–S6).