TERT and neoplasm: Animal experimentation has shown that ectopic expression of TERT promotes tumor formation and growth [57,58,59,60], and its constitutive overexpression increases the survival and replicative activity of tumor cells, even in the absence of growth factors, oxygen, or glucose [57,61,62], while conversely a lack of TERT activity promotes apoptosis [63,64,65,66,67,68].