To gain a deeper insight into the combined role of PTEN and TP53 deletions in lung cancer, we have generated mouse models in which both Pten and Trp53 are disrupted in lung epithelial cells, either widely (by means of an Ad5-CMVcre virus) or in a cell-type restricted manner (using an Ad5-K5cre virus) and determine its effect on tumor formation. Here, PTEN is linked to lung cancer.