The human LADC signature developed here, TCGA-Gillete_huLADC, but not signatures for other lung cancer types (small cell lung cancer), was significantly enriched in our mouse tumors, indicating that the expression characteristics of the mouse tumors developed by the inactivation of the Trp53 and Pten genes are similar to human LADC (Figure 6C). This evidence concerns the gene TP53 and lung cancer.