None of the immunohistochemical or molecular tools used to diagnose the different subtypes of HCA are useful at this point, because their expression can be modified in malignant lesions; LFABP can be decreased in HCC [56], CRP can be expressed by some HCCs [57], and CTNNB1 mutations are commonly found in HCC. The gene discussed is CRP; the disease is hepatocellular carcinoma.