CD8A and esophageal squamous cell carcinoma: The study focusing on esophageal squamous cell carcinoma (ESCC) revealed that first-, second-, and higher-order features describing grey-level distribution (e.g., interquartile range, entropy, cluster prominence) and fine textures (short runs) could predict CD8+ TILs (validation AUC = 0.728, 95% CI: 0.562−0.894) [60].