In this context, radiomic signatures between studies were dissimilar: first- and second-order GLRLM features (short runs) were good predictors of different cytotoxic TIL levels in glioblastoma (AUC = 0.710; 95% CI: NA) [59], while second-order GLSZM features (variance of grey-levels within size zone volumes) could determine CD8+ TIL-dominant HGG lesions [36]. Here, CD8A is linked to glioblastoma.