Interestingly, in the case of cancer, IL-36α, IL-36β, and IL-36γ showed distinct potencies in driving the proliferation of HT29 colon cancer cells, with IL-36γ showing the highest proliferative effect through the activation of the ERK and PI3K/AKT signaling pathways [25]. Here, AKT1 is linked to malignant colon neoplasm.