WNT1 and neoplasm: In their study on the model of MMTV-Wnt1 mouse mammary gland cancer transplanted into ovariectomized (OVX) mice, Williams et al. observed that in mice on high-fat diet a vitamin D-supplemented diet or calcitriol injections slowed down tumor growth and influenced the pathways dysregulated by obesity in both tumor cells and the surrounding breast adipose tissue.